Page 33 - Blog
- - November 10, 2014
The EVOM2 is the classic, hand-held instrument for making Trans Epithelial Electrical Resistance (TEER) measurements. The REMS system adds a robot and data recording for automated TEER measurements. There may be times when you don't have a robot, but would still like to have the data recording capabilities of the REMS system. With a little ingenuity, you can do just that. Here, we will show you how you can add data recording to your standard EVOM2.
- - October 20, 2014
A low-noise amplifier like the DAM50 is an excellent choice for EEG recording in rodents. WPI's amplifiers were engineered for the bio-medical researcher. While 20-30μV of noise is common in bio-amplifiers, WPI’s DAM series amplifiers generate 0.4μV RMS (root mean squared) at 0.1-100Hz. (That’s equal to about 2μV peak to peak.) This setup shows one way such recordings could be made. The RC1 electrode works well for rats, and the EP1 is more suitable for mouse cranial application.
For this application, you will need the following equipment:
- (1) DAM50 amplifier
- (1) MD4R micromanipulator
- (2) M3301EH electrode holders
- (2) Profile A single tungsten metal electrodes
- (1) M10 stand
- (1) 5052 steel base plate
- (1) 5470 cable
- (1) electrode (RC1 or EP1)
Rat Cranial Applications
- - October 16, 2014
What's the difference between cleaning, disinfecting and sterilizing? Let's take a look. This is the first in a series of four videos to discuss some best practices in caring for your surgical instrument investment.
In video #2, you can see how to manually clean surgical instruments. It is loaded with tips. This video is the second in a series of four to discuss some best practices in caring for your surgical instrument investment.
In video #3, you can see how to mechanically clean surgical instruments using an ultrasonic cleaner. This video is loaded with tips. This video is the third in a series of four to discuss some best practices in caring for your surgical instrument investment.
In video #4, you get some practical tips on sterilizing your surgical instruments and using an autoclave.This video is the fourth in a series of four to discuss some best practices in caring for your surgical instrument investment.
WPI was founded by a researcher who built electrophysiology equipment...more
- - October 09, 2014
World Precision Instruments chemist Nikki Scafa demonstrates how to calibrate your ISO-OXY-2 or OXELP oxygen sensor with the TBR4100 free radical analyzer. For more information on biosensors, see www.wpiinc.com/biosensors.
- - August 04, 2014
Micro4™ from World Precision Instruments is an easy-to-use but very capable controller for WPI's Nanoliter Injector and UMP3 UltraMicropPump.
- - July 20, 2014
WPI's Nanoliter 2010 Microinjection Pump is ideal for many applications, including zebrafish, xenopus oocytes and drosophila. MICRO4, an optional microprocessor-based controller, can provide an "intelligent" and easy-to-use interface to up to four Nanoliter Injectors. Operating parameters are set with the membrane key-pad and LCD display.
- - July 13, 2014
Gas anesthesia with Isoflurane is quickly becoming the standard method of general anesthesia for rats and mice in biomedical research. The advantages of using gas anesthesia for in-vivo examinations include:
- Fewer complications than injectable agents
- Allows for longer exam duration
- Easier administration and control
- Readily incorporated into existing procedures
- Level plane of anesthesia
- Minimal animal handling/Less stress
- No controlled substances required
- Quick recovery time
- Economical and versatile
These are designed to tightly and flexibly fit on various size rodents. The optically clear masks are designed to provide access to the eyes and head of the rodent. These masks provide stability of the animal for examinations and surgery. And, they may be trimmed for custom applications.
- Anatomically correct fit to mouse and rat
- Zero leakage
- Zero dead space
- Reinforced ports for longer product life
- Mask can be used in the range of 400–1000 cc/min.
- Ports swivel 360°
The masks come in four sizes...more
- - July 01, 2014
Watch as Barney and Kelly Boyce set up an InVivo microscope chamber. Ideal for live cell imaging, the chambers, along with heaters, carbon dioxide and oxygen controllers and stagetop environments are sold by World Precision Instruments.
- - June 30, 2014
In this JoVE video you can observe as the researchers perform an intraluminal middle cerebral artery occlusion (MCAO) on a mouse. The MCAO model is the most frequent used model among experimental ischemic stroke models.
WPI instruments used in this application include:
SuperCut Iris scissor, straight 14218 Vannas micro-scissor, straight 14003 Dumont fine tip forceps 503290 Vessel clip 14120 High Frequency Desiccator 900 504043 Silicone RTV adhesive 1571 Thermal Cautery Unit 501292 BAT-12 BAT-12R Ansari, S., Azari, H., McConnell, D. J., Afzal, A., Mocco, J. Intraluminal Middle Cerebral Artery Occlusion (MCAO) Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Mice. J. Vis. Exp. (51), e2879, doi:10.3791/2879 (2011).
- - June 24, 2014
Chiara Cianciolo Cosentino, at the University of Pittsburgh, describes how she uses intravenous microinjections of zebrafish larvae to study acute kidney injury in this JoVE video. You can also watch this video on JoVE. WPI equipment shown in this video includes:
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